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Dianova公司為德國(guó)著名的病理免疫組化產(chǎn)品供應(yīng)商,具備的抗體制備工藝及嚴(yán)格的質(zhì)控系統(tǒng),產(chǎn)品在上享有良好的聲譽(yù)。
克隆號(hào)為H09的IDH1(isocitrate dehydrogenase 1, 異檸檬酸鹽脫氫酶1)鼠單克隆抗體為Dianova公司近期推出的優(yōu)秀產(chǎn)品之一,此抗體可特異性的檢測(cè)腦組織腫瘤中IDH1基因的R132H點(diǎn)突變。IDH1基因的第132密碼子的雜合突變是II 和III級(jí)神經(jīng)膠質(zhì)瘤(根據(jù)WHO的腫瘤學(xué)分類(lèi))的頻發(fā)事件。在大約70%的星形膠質(zhì)細(xì)胞瘤和少突神經(jīng)膠質(zhì)細(xì)胞瘤可發(fā)現(xiàn)IDH1基因的R132H點(diǎn)突變。
IDH1基因R132H突變?cè)诓糠帜X腫瘤中的頻發(fā)現(xiàn)象使克隆號(hào)為H09的IDH1抗體可高靈敏性和高特異性的用于此類(lèi)腫瘤的鑒別診斷中:如從原發(fā)性膠質(zhì)母細(xì)胞瘤中區(qū)分出間變性星形細(xì)胞瘤、從毛細(xì)胞型星形細(xì)胞瘤或室管膜(細(xì)胞)瘤中區(qū)分出彌漫性星形細(xì)胞瘤(WHO分類(lèi)II級(jí)),也可以用于具有IDH1突變的腫瘤細(xì)胞浸潤(rùn)前沿的與反應(yīng)性神經(jīng)膠質(zhì)增多癥的區(qū)分。因此,由于其高靈敏性和高特異性,此抗體在腦部腫瘤的分類(lèi)分級(jí)中以及在檢測(cè)單一或少量浸潤(rùn)腫瘤細(xì)胞時(shí)是非常有用的。
貨號(hào) | 品名 | 報(bào)價(jià) | 包裝 | 品牌 | ** |
DIA-H09 | Anti-IDH1 R132H (Hu) from Mouse (Clone: H09)-unconj. | 9296 | 100ug | dianova | 6000 |
DIA-310-M | Anti-CD31 (Ms) from Rat (Clone: SZ31)-unconj. | 2600 | 20ug | dianova | 1500 |
DIA-100-M | Anti-Fibroblasten (CD90) (Hu) from Mouse (Clone: AS02) -unconj. | 2600 | 20ug | dianova | 1500 |
DIA-300-LM | Anti-CD30 (Ki-1) (Hu) from Mouse (Clone: Ber-H2)-unconj. | 2600 | 20ug | dianova | 1500 |
DIA-326-LM | Anti-EpCAM (CD326) (Hu) from Mouse (Clone: Ber-EP4)-unconj. | 2600 | 120Test | dianova | 1500 |
DIA-333-M | Anti-TRAF1 (Hu) from Mouse (Clone: Ber-TRAF1)-unconj. | 2600 | 20ug | dianova | 1500 |
DIA-530-M | Anti-p53 (Hu) from Mouse (Clone: CC53) -unconj. | 2600 | 0.1ml | dianova | 1500 |
DIA-670-M | Anti-Ki-67/MIB1 (Hu) from Mouse (Clone: Ki-67P) -unconj. | 2600 | 0.1ml | dianova | 1500 |
DIA-700-M | Anti-GFAP (Hu) from Mouse (Clone: IF3) -unconj. | 2600 | 0.1ml | dianova | 1500 |
DIA-H09-M | Anti-IDH1 R132H (Hu) from Mouse (Clone: H09)-unconj. | 2600 | 20ug | dianova | 1500 |
DIA-310 | Anti-CD31 (Ms) from Rat (Clone: SZ31)-unconj. | 8714 | 100ug | dianova | 5200 |
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