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SCHIRCKS 16.411 說明書

發(fā)布時間:2017/8/10      點擊次數(shù):1148

世界*實驗材料供應(yīng)商 Schircks正式授權(quán)上海起發(fā)為其中國代理, Schircks在一直是行業(yè)的*,一直為廣大科研客戶提供zui為的產(chǎn)品和服務(wù),上海起發(fā)一直秉承為中國科研客戶帶來的產(chǎn)品,的服務(wù),簽約 Schircks就是為了給廣大科研客戶帶來更加完善的產(chǎn)品和服務(wù),您的滿意將是我們zui大的收獲

Schircks中國代理, Schircks上海代理, Schircks北京代理,Schircks廣東代理, Schircks江蘇代理Schircks湖北代理,Schircks天津,Schircks黑龍江代理,Schircks內(nèi)蒙古代理,Schircks吉林代理,Schircks福建代理, Schircks江蘇代理, Schircks浙江代理, Schircks四川代理,

 

Schircks Laboratories由B. Schircks博士在瑞士成立,1980合成蝶啶。該公司是獨立經(jīng)營的。schircks實驗室已經(jīng)停止生產(chǎn)四氫生物蝶呤。BIOMARIN已經(jīng)接管了美國市場,默克雪蘭諾公司歐洲市場。他們將繼續(xù)擴大。他們是負責(zé)供應(yīng)(鹽酸沙丙蝶呤呤)片劑(含量)。
超過100的schircks實驗室其他蝶啶類化合物主要用于科學(xué)和臨床診斷應(yīng)用的合成。我們不斷開發(fā)和改進合成,并開始新的合成,以滿足世界各地的研究和開發(fā)小組的需求。

 

Methotrexate

Product No. 16.411

Synonym: Amethopterin, N-methylamino}benzoyl}-L-glutamic acid

Abbreviation used: MTX

Description

Yellow to orange brown crystalline powder

 

 

Biochemistry

Methotrexate is an antimetabolite. It is an inhibitor of dihydrofolate reductase. MTX acts by

 

altering the body's use of folic acid (a vitamin), which is needed for cell growth. It is

 

suspected that this interference with folic acid is an important reason for methotrexate's

 

benefit in rheumatoid arthritis.

 

 

 

Solubility

MTX is practically insoluble in water. It is sparingly soluble in 0.01 M NaOH pH 10.0,

 

(0.25 g/100 g 0.01 M NaOH (22°C)). Ultrasonication may be used to improve dissolution.

HPLC Conditions

column

 

Waters Spherisorb S5-ODS1

 

 

 

eluant

 

10 mM Na2HPO4 pH 6.0 / Methanol (19:1)

 

flow rate

 

1 ml/min

 

 

 

 

wavelength

 

254 nm

 

 

 

 

solution

 

1 mg/ml 0.01 M NaOH

 

 

Purity: HPLC

>98.5%. Related substances are N-methylfolic acid, 4-aminofolic acid, 2,4-diami0-

 

methylpteroic acid and 10-methylpteroic acid.

 

 

Stability

Methotrexate powder is stable at room temperature for at least 3 months. It is hygroscopic.

 

A 1 mM solution of MTX in 0.01 M NaOH is very stable. HPLC analysis of the 1 mM solution

 

after 7 days at room temperature showed no degradation.

Storage

Keep the powder dry in amber vials at –20°C or colder. Methotrexate can be transported

 

without the use of dry ice.

 

 

 

Uses

MTX was first developed to treat certain types of cancer. It is routinely used at high doses

 

as a cancer therapy and is also used at much lower doses to treat neoplastic diseases,

 

severe psoriasis, Crohn's disease and adult rheumatoid arthritis. Our product is sold for

 

laboratory use only.

 

 

 

Precautions

Highly Toxic. Use Special Handling precautions. Avoid inhalation and skin contact.

 

Side effects to the use of this drug may include suppression of bone marrow production of

 

blood cells, hepatitis, and others.

 

 

 

References

"Taber's Cyclopedic Medical Dictionary", Copyright © 2001 by F. A. Davis Co., Phil., PA.

 

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6:我們*代理的品牌有:Antibody Research Corporation,arcticzymes,Biorelevant,AmberGen, Inc. ,clemente-associates,clodronaiposomes,Columbia Biosciences,enzyme research,Gene Bridges GmbH,Genovis,AmberGen, Inc.  Biotechnology GmbH,Haematologic Technologies HTI Haemtech,hookelabs,Immudex,Innovative Research of America,inspiralis ,List Biological Laboratories, Inc.,lumafluor,Microsurfaces,multiplicom,nanotools,Pel-Freez Biologicals,pentapharm,progen,Protein Ark,QA-Bio,Inc,QA-Bio,IncQuickZyme Biosciences,Teknova,TriLink BioTechnologies, Inc.,Zyagen Laboratories 等

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